Prevention and treatment of experimental autoimmune encephalomyelitis induced mice with 1, 25-dihydroxyvitamin D3. ABSTRACT Multiple sclerosis (MS) is a complex inflammatory and demyelinating disease of the central nervous system (CNS) frequently starts in young adulthood. Demyelination, inflammatory and axonal damage in the CNS is the pathological hallmark of experimental autoimmune encephalomyelitis (EAE), an animal model…
Association study of copy number variation in BMP8A gene with the risk of ankylosing spondylitis in Iranian population. Journal of cellular biochemistry. Abstract Background Copy number variation (CNV) of DNA segments has been considered as an important component of genetic variation, affecting the quality and quantity of gene expression. Bone morphogenic protein 8A (BMP8A) has…
FadA-positive Fusobacterium nucleatum is prevalent in the biopsy specimens of Iranian patients with colorectal cancer. New Microbes and New Infections. Abstract Introduction FadA-positive Fusobacterium nucleatum : Recently, Fusobacterium nucleatum has been increasingly implicated as a causative agent of various diseases, e.g., inflammatory bowel disease. Moreover, the gastrointestinal tracts of patients with colorectal cancer (CRC) also have…
MOLECULAR MECHANISM OF DISRUPTION OF BLOOD BRAIN BARRIER IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. Abstract: Introduction Blood brain barrier (bbb) is made by endothelial capillary cells. these cells use complex tight junctions to restrict paracellular diffusion. In EAE (experimental autoimmune encephalomyelitis ) animal model of multiple sclerosis we increase permeability of blood brain barrier. Many articles show…
THE ROLE OF TH17 CELLS AS A NEW THERAPEUTIC PERSPECTIVE IN MULTIPLE SCLEROSIS. Abstract: Introduction: Multiple sclerosis is a chronic, demyelinating and progressive inflammatory disorder affecting the central nervous system. Ms is mediated by cd4+t cells with proinflammatory t helper (th) 1 and th17 phenotypes… View full article
NANOSTRUCTURE MEDIATED DRUG DELIVERY SYSTEMS ACROSS BLOOD BRAIN BARRIER Abstract: Introduction: Nanotechnologies are materials and devices that have a functional organization in at least one dimension on the nanometer (i.e., one billionth of a meter) scale, ranging from a few to about 100 nanometers. many fda approved drugs currently available in the market have limitations…
MICRORNAS AS NOVEL KEY PLAYERS IN MULTIPLE SCLEROSIS. Abstract: Introduction Multiple sclerosis (ms) is a chronic, neurodegenerative and progressive inflammatory disorder that attacks the central nervous system. MicroRNAs (miRNAs) are the class of small non-coding RNA with post-transcriptional gene expression functions… View full article
In 1, 25-Dihydroxyvitamin D3 ameliorates 4texperimental autoimmune encephalomielItis in C57BL/6 mice via polarization of T regulatory and T helper 2 cells and inhibiting T helper 17 subset Abstract: Introduction The experimental autoimmune encephalomyelitis (eae) is an animal model for human multiple sclerosis. Vitamin D has several reported immunomodulatory properties including the reduced generation of pro-inflammatory…
Hespiridin alleviates Experimental autoimmune encephalomyelitis in C57BL/6 mice via regulating Treg and T helper 2 polarizations. Abstract: Introduction Hespiridin alleviates Experimental autoimmune encephalomyelitis in C57BL/6 mice via regulating Treg and T helper 2 polarizations. Multiple sclerosis (ms) is the most abundant central nervous system inflammatory disease, which is due to the reaction of auto reactive…
Comparison of the expression levels of Fas and Apaf-1 genes in systemic sclerosis dermal fibroblasts. Tehran University Medical Journal TUMS Publications. Abstract Background: Comparison of the expression levels of Fas and Apaf-1 genes in systemic sclerosis dermal fibroblasts. Systemic sclerosis (SSc) is an autoimmune rheumatic connective tissue disease. In normal wound healing process, fibroblasts are…