In 1, 25-Dihydroxyvitamin D3 ameliorates 4texperimental autoimmune encephalomielItis in C57BL/6 mice via polarization of T regulatory and T helper 2 cells and inhibiting T helper 17 subset
Abstract:
Introduction
The experimental autoimmune encephalomyelitis (eae) is an animal model for human multiple sclerosis. Vitamin D has several reported immunomodulatory properties including the reduced generation of pro-inflammatory cd4+th1 cells and the increase in levels of the anti-inflammatory th2 subset. less clear has been the impact of vitamin d on the pro-inflammatory th17 subset, and whether and how vitamin d may preferentially drives the polarization of one of the t helper subsets. In 1, 25-Dihydroxyvitamin D3 ameliorates 4texperimental autoimmune encephalomielItis in C57BL/6 mice via polarization of T regulatory and T helper 2 cells and inhibiting T helper 17 subset …