MOLECULAR MECHANISM OF DISRUPTION OF BLOOD BRAIN BARRIER IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS.
Blood brain barrier (bbb) is made by endothelial capillary cells. these cells use complex tight junctions to restrict paracellular diffusion. In EAE (experimental autoimmune encephalomyelitis ) animal model of multiple sclerosis we increase permeability of blood brain barrier. Many articles show that angiogenesis has a significant role in disruption of BBB.